David M Findlay Selected Research

drozitumab

9/2017	Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma.
12/2014	Doxorubicin overcomes resistance to drozitumab by antagonizing Inhibitor of Apoptosis Proteins (IAPs).

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David M Findlay Research Topics

Disease

13	Osteolysis 12/2019 - 10/2006
10	Neoplasms (Cancer) 09/2017 - 06/2002
9	Bone Resorption 01/2018 - 01/2004
7	Osteosarcoma (Osteogenic Sarcoma) 09/2017 - 06/2002
7	Breast Neoplasms (Breast Cancer) 03/2016 - 05/2006
6	Inflammation (Inflammations) 12/2017 - 01/2005
4	Hypoxia (Hypoxemia) 09/2017 - 10/2014
4	Neoplasm Metastasis (Metastasis) 09/2017 - 05/2009
4	Bone Diseases (Bone Disease) 01/2017 - 01/2004
3	Bone Fractures (Bone Fracture) 01/2017 - 07/2004
3	Osteoporosis 08/2013 - 04/2005
3	Hypercalcemia (Milk Alkali Syndrome) 05/2013 - 08/2008
2	Joint Diseases (Joint Disease) 01/2018 - 01/2007
2	Arthralgia (Joint Pain) 01/2018 - 08/2007
2	Bacterial Infections (Bacterial Infection) 04/2015 - 01/2012
2	Osteoarthritis 03/2011 - 04/2005
2	Rheumatoid Arthritis 03/2011 - 08/2006
2	Multiple Myeloma 03/2009 - 09/2003
2	Necrosis 01/2009 - 10/2006
1	Osteomyelitis 01/2018
1	Disease Progression 01/2018
1	Infections 01/2018
1	Wounds and Injuries (Trauma) 12/2016
1	Osteoporotic Fractures 01/2016
1	Knee Osteoarthritis 01/2016
1	Bone Neoplasms (Bone Cancer) 04/2015
1	Rickets (Rachitis) 10/2014
1	Crush Injuries 01/2013
1	Body Weight (Weight, Body) 01/2013
1	Tibial Plateau Fractures 01/2013
1	Arthritis (Polyarthritis) 01/2009

Drug/Important Bio-Agent (IBA)

8	LigandsIBA 08/2014 - 01/2005
6	Polyethylene (Polythene)IBA 01/2019 - 10/2006
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2011 - 06/2002
5	CalciumIBA 09/2015 - 08/2008
4	CytokinesIBA 01/2013 - 06/2002
3	Pharmaceutical PreparationsIBA 12/2017 - 04/2015
3	TH 302IBA 09/2017 - 02/2015
3	ProdrugsIBA 09/2017 - 02/2015
3	MineralsIBA 03/2016 - 01/2004
3	Calcitonin Receptors (Calcitonin Receptor)IBA 09/2015 - 08/2008
3	Vitamin D FDA LinkGeneric 10/2014 - 06/2007
3	OsteoprotegerinIBA 08/2014 - 03/2009
3	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 05/2013 - 08/2008
3	Messenger RNA (mRNA)IBA 07/2004 - 09/2003
2	ultra-high molecular weight polyethylene (UHMWPE)IBA 01/2019 - 03/2016
2	MetalsIBA 01/2019 - 10/2006
2	Biological ProductsIBA 01/2018 - 02/2011
2	DNA (Deoxyribonucleic Acid)IBA 09/2017 - 02/2015
2	drozitumabIBA 09/2017 - 12/2014
2	RANK LigandIBA 01/2017 - 10/2006
2	Proteins (Proteins, Gene)FDA Link 01/2016 - 09/2003
2	Doxorubicin (Adriamycin)FDA LinkGeneric 02/2015 - 12/2014
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 08/2014 - 03/2011
2	Zoledronic Acid (Zometa)FDA Link 07/2010 - 05/2009
2	Diphosphonates (Bisphosphonates)IBA 05/2009 - 01/2004
2	Calcitriol (Calcijex)FDA LinkGeneric 08/2008 - 01/2004
2	Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA 10/2006 - 01/2005
1	AlloysIBA 01/2019
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 01/2019
1	Cathepsin KIBA 01/2019
1	titanium alloy (TiAl6V4)IBA 01/2019
1	human TNFSF10 proteinIBA 09/2017
1	azomycinIBA 09/2017
1	isophosphamide mustard (IPAM)IBA 09/2017
1	Acid PhosphataseIBA 01/2017
1	Heme (Haem)IBA 01/2017
1	EnzymesIBA 01/2017
1	Eosinophil PeroxidaseIBA 01/2017
1	Peroxidase (Myeloperoxidase)IBA 01/2017
1	Parathyroid Hormone (Parathormone)IBA 12/2016
1	Hormones (Hormone)IBA 12/2016
1	GelsIBA 12/2016
1	Paclitaxel (Taxol)FDA LinkGeneric 03/2016
1	Polysaccharides (Glycans)IBA 01/2016
1	Transcription Factors (Transcription Factor)IBA 10/2014
1	25-Hydroxyvitamin D3 1-alpha-Hydroxylase (25 Hydroxyvitamin D3 1 alpha Hydroxylase)IBA 10/2014
1	LuciferasesIBA 08/2014
1	p38 Mitogen-Activated Protein KinasesIBA 01/2013
1	Dihydrotachysterol (AT 10)IBA 01/2013
1	TitaniumIBA 01/2012
1	TWEAK ReceptorIBA 03/2011
1	Neutralizing AntibodiesIBA 03/2011
1	apomabIBA 10/2009
1	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 01/2009
1	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 01/2009
1	Biotin (Vitamin H)FDA Link 01/2009
1	1,25-dihydroxyvitamin DIBA 08/2008

Therapy/Procedure

4	Hip Replacement Arthroplasty (Total Hip Replacement) 12/2019 - 12/2013
4	Prostheses and Implants (Prosthesis) 12/2019 - 10/2011
4	Cell Transplantation 09/2017 - 03/2009
3	Therapeutics 04/2015 - 06/2002
3	Drug Therapy (Chemotherapy) 02/2015 - 06/2002
2	Replacement Arthroplasty 01/2018 - 01/2007
2	Bone Transplantation (Bone Grafting) 04/2014 - 01/2013
1	Bone Plates (Bone Plate) 01/2018
1	Bone-Implant Interface 01/2016
1	Reoperation 12/2013
1	Joint Prosthesis 10/2011
1	Treatment Delay 10/2009